OBOE - Strategic research center for Organic BioElectronics

Goal

The goal of the OBOE project is to record and regulate signals in individual cells to control stem cell differentiation, steer cell-to-cell signalling and to achieve neural interconnects using organic electronic ion-pumps; surface tension and texture switches; macromolecule dispensers; cell wall through-puts conjugated polyelectrolyte recorders.

Participants

Acreo, Karolinska Institutet (KI) and Linköpings Universitet(IFM, ITN,ICG)

Projects within OBOE

* Live cell Staining (IFM, KI)
* Active and smart hydro-gel scaffold (AcSS)systems with applications in stem cell therapy (ITN, KI)
* Using POWTs to monitor neuroplaques in Alzheimer's disease (IFM, KI)
* Cell lineage analysis (ICG, KI)
* Control of stem cell differentiation and proliferation by surface energy changes in conjugated polymers (ITN, KI)
* Surface switches to control cell adhesion and realease from a conjugated polymer (ITN, KI)
* Soft hydrogel-based electrodes for neural interconnects (ITN, KI)
* Synthesis in characterisation of CPE photonic probes (IFM, PK)
* Surface topography/surface energy switching(ITN, IFM, KI, PK)
* Stem cell differentiation (IFM, KI)
* Neural electrodes and interfaces (IFM, KI)
* Steering and monitoring neural stem cell differentiation with polymers and macromolecular delivery devices (MaDDs) (IFM, KI)
* Communication with biological systems using an organic electronic ion-pump (ITN, KI)
* Microfluidic systems to deliver defined biological stimuli to selected cells (ITN, KI)
* Real-time live imaging in animal models using CPE (IFM, KI, PK)
* Development of a novel line of tools for molecular biology based on conjugated polyelectrolytes and bacteria (IFM, KI, PK)
* Conjugated polymer probes and polymer wires for making biological fibers with electronic functionality (IFM, KI)